Clinical Protocol

7-Day Pyruvate Optimization Plan

A focused nutrition strategy to optimize pyruvate oxidation, ensuring efficient energy production and preventing metabolic backup.

Protocol Objectives
Thiamine (B1) Saturation

Pyruvate Dehydrogenase (PDH) requires Thiamine. Deficiency causes pyruvate to back up and convert to lactate.

Lipoic Acid Support

Alpha-Lipoic Acid is a critical cofactor for pyruvate metabolism. Include sources like spinach, broccoli, and organ meats.

Stable Glucose

Pyruvate is the end product of glycolysis. Stabilizing glucose input prevents 'flooding' the system with more pyruvate than mitochondria can handle.

Magnesium Cofactor

Magnesium is required for the ATP-dependent steps of glycolysis that produce pyruvate.

Day 1 Thiamine Loading
Breakfast
Sunflower Seed Oatmeal
Seeds are top tier B1 sources.
Lunch
Pork Chop & Cabbage
Pork is the highest B1 meat.
Dinner
Asparagus & Salmon
Asparagus is a good plant source of B1.
Day 2 Lipoic Acid
Breakfast
Spinach & Tomato Omelet
Spinach contains lipoic acid.
Lunch
Broccoli & Beef Stir-Fry
Broccoli supports PDH complex.
Dinner
Brussels Sprouts & Chicken
Cruciferous veg boost ALA.
Day 3 Glycolysis Control
Breakfast
Greek Yogurt & Flax
Low glycemic start.
Lunch
Lentil Salad
Slow release glucose = steady pyruvate.
Dinner
Zucchini Lasagna (No Pasta)
Low carb reduces pyruvate load.
Day 4 Magnesium
Breakfast
Avocado Toast
Magnesium rich fat source.
Lunch
Black Bean Soup
Legumes offer Mg + B1.
Dinner
Mackerel & Swiss Chard
High mineral greens.
Day 5 Mitochondrial Fat
Breakfast
Eggs & Macadamia Nuts
Healthy fats spare glucose use.
Lunch
Sardine & Arugula Salad
Omega-3s support mitochondrial membrane.
Dinner
Curried Cauliflower & Tofu
Tofu provides manganese/magnesium.
Day 6 B-Complex Day
Breakfast
Whole Grain Rye Bread & Eggs
Rye is high in B-vitamins.
Lunch
Liver Pâté & Crackers
Liver is nature's multivitamin.
Dinner
Roast Chicken & Squash
Balanced macro meal.
Day 7 Metabolic Synergy
Breakfast
Chia Pudding
Fiber modulates absorption.
Lunch
Kale & Quinoa Bowl
Complete protein and minerals.
Dinner
Steak & Mushrooms
Mushrooms offer B-vitamins.

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Protocol Guidelines & Science
Raw vs Cooked

Some B-vitamins are heat sensitive. Include some raw nuts, seeds, or salads daily to ensure optimal intake.

Alcohol Depletion

Alcohol blocks thiamine absorption. If pyruvate is an issue, avoiding alcohol is the single most effective dietary change.

Scientific References:
1. Patel, M. S., & Korotchkina, L. G. (2006). 'Regulation of the pyruvate dehydrogenase complex.' Biochemical Society Transactions.
2. Stacpoole, P. W. (2012). 'The pyruvate dehydrogenase complex as a therapeutic target for metabolic diseases.' Drug Discovery Today.
3. Lonsdale, D. (2006). 'A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives.' eCAM.