Clinical Protocol

7-Day Leptin Sensitivity Reset

A nutritional strategy to reverse leptin resistance, restore satiety signaling, and reduce chronic inflammation causing hormonal blockages.

Protocol Objectives
Lower Triglycerides

High triglycerides block leptin from crossing the blood-brain barrier. Reduce carbs and fructose to lower triglycerides immediately.

Anti-Inflammatory

Hypothalamic inflammation causes leptin resistance. Eliminate inflammatory seed oils and processed foods.

Protein at Breakfast

A high-protein breakfast (30g+) resets the daily satiety clock and improves leptin sensitivity for the rest of the day.

No Snacking

Allow distinct 4-5 hour gaps between meals to let insulin levels drop, as high insulin blocks leptin signaling.

Day 1 Triglyceride Drop
Breakfast
Steak & Eggs
High protein, zero carb to drop TGs.
Lunch
Grilled Chicken Caesar (No Croutons)
High protein, healthy fats.
Dinner
Baked Cod & Steamed Broccoli
Very light dinner to aid sleep.
Day 2 Satiety Signaling
Breakfast
Salmon & Avocado Plate
Protein + Fat = Satiety.
Lunch
Turkey Meatballs & Zucchini
Lean protein focus.
Dinner
Beef Stir-Fry
Protein helps hypothalamus signaling.
Day 3 Gut Inflammation
Breakfast
Protein Smoothie (Collagen)
Gut healing amino acids.
Lunch
Bone Broth Soup with Chicken
Reduces gut permeability.
Dinner
Poached Fish & Asparagus
Easy to digest, anti-inflammatory.
Day 4 Omega-3 Balance
Breakfast
Sardines & Eggs
Powerful anti-inflammatory start.
Lunch
Walnut & Spinach Salad
ALA Omega-3s.
Dinner
Salmon & Roasted Cauliflower
DHA helps brain sensitivity.
Day 5 Rhythm Reset
Breakfast
3-Egg Omelet with Mushrooms
Eat within 30 mins of waking.
Lunch
Grilled Shrimp Salad
Light, high protein.
Dinner
Roast Chicken Leg & Kale
Eat 3-4 hours before bed.
Day 6 Fiber Volume
Breakfast
Chia Pudding (Protein Powder)
Fiber aids satiety signals.
Lunch
Giant Cobb Salad
Volume eating for stretch receptors.
Dinner
Lean Beef Chili (No Beans)
High protein, tomato lycopene.
Day 7 Maintenance
Breakfast
Turkey Sausage & Eggs
Savory start prevents cravings.
Lunch
Tuna Salad & Cucumber Boats
Hydrating and filling.
Dinner
White Fish & Green Beans
Clean, simple proteins.

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Protocol Guidelines & Science
The Palatability Trap

Avoid 'hyper-palatable' food combinations (high fat + high sugar). These bypass the brain's satiety stop-signals, worsening leptin resistance.

Circadian Alignment

Eat a substantial breakfast. Skipping breakfast can disrupt the circadian rhythm of leptin, leading to night-time cravings and resistance.

Scientific References:
1. Banks, W. A. (2008). 'The blood-brain barrier as a cause of obesity.' Current Pharmaceutical Design.
2. Lustig, R. H. (2006). 'Childhood obesity: behavioral aberration or biochemical drive?' Nature Clinical Practice.
3. Myers, M. G., et al. (2010). 'Mechanisms of leptin action and leptin resistance.' Annual Review of Physiology.