Clinical Protocol

7-Day Homocysteine Methylation Plan

A nutrition strategy to lower toxic homocysteine levels by flooding the body with methylation donors (B12, Folate, B6, Betaine).

Protocol Objectives
The B-Trio

Folate (B9), B12, and B6 are non-negotiable. They are the cofactors required to recycle homocysteine back into methionine or cysteine.

Foliage for Folate

Dark leafy greens are the best source of natural folate (not synthetic folic acid). Aim for 2 cups daily.

Betaine (TMG)

Betaine creates a 'backup' pathway to lower homocysteine in the liver. Beets and spinach are top sources.

Reduce Methionine?

Excess muscle meat increases methionine load. Balancing meat with glycine-rich foods (bone broth, skin) helps buffer this.

Day 1 Folate Loading
Breakfast
Spinach & Mushroom Omelet
Spinach is king for folate.
Lunch
Lentil Soup
Lentils are folate dense.
Dinner
Asparagus & Salmon
Asparagus provides 134mcg folate.
Day 2 B12 Boost
Breakfast
Sardines on Toast
Sardines are B12 powerhouses.
Lunch
Clam Chowder (Dairy free)
Clams have extreme B12 levels.
Dinner
Beef Liver & Onions
The ultimate B-vitamin food.
Day 3 Betaine
Breakfast
Wheat Bran Cereal
Wheat bran is high in betaine.
Lunch
Beet & Goat Cheese Salad
Beets = Betaine.
Dinner
Shrimp & Spinach
Shrimp has moderate betaine.
Day 4 B6 Support
Breakfast
Banana & Walnuts
Bananas are a B6 fruit source.
Lunch
Chickpea Salad
Chickpeas are high in B6.
Dinner
Turkey Breast & Sweet Potato
Turkey is rich in B6.
Day 5 Glycine Balance
Breakfast
Bone Broth (1 cup)
Glycine buffers methionine.
Lunch
Chicken Skin-on & Salad
Skin provides glycine.
Dinner
Slow Cooked Roast
Collagen breaks down to glycine.
Day 6 Greens & Beans
Breakfast
Avocado & Black Beans
Folate combination.
Lunch
Large Kale Caesar
Kale provides folate/B6.
Dinner
Liver (or Supplement) & Broccoli
Weekly organ meat dose.
Day 7 Maintenance
Breakfast
Eggs & Spinach
Choline (in eggs) converts to betaine.
Lunch
Quinoa & Edamame
Folate rich grain.
Dinner
Salmon & Brussels Sprouts
Complete methylation meal.

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Protocol Guidelines & Science
MTHFR Mutation

If you have the MTHFR gene variant, you may need methylated B-vitamins (Methylfolate/Methylcobalamin) supplements in addition to diet.

Limit Coffee

Heavy coffee consumption (>4 cups) can deplete B-vitamins and raise homocysteine. Keep it to 1-2 cups.

Scientific References:
1. Homocysteine Studies Collaboration. (2002). 'Homocysteine and risk of ischemic heart disease and stroke.' JAMA.
2. Selhub, J. (1999). 'Homocysteine metabolism.' Annual Review of Nutrition.