Clinical Protocol

7-Day ApoE Risk Management Plan

A preventive nutrition strategy for ApoE4 carriers (and general cognitive health) focusing on low inflammation, insulin sensitivity, and heavy metal detox.

Protocol Objectives
Insulin Sensitivity

ApoE4 brains struggle to use glucose as fuel (Type 3 Diabetes). A low-glycemic or mild ketogenic diet provides ketones as alternative brain fuel.

Alcohol Cessation

ApoE4 carriers are hyper-sensitive to alcohol's neurotoxic effects. Strict limitation or elimination is recommended.

DHA Saturation

ApoE4 carriers transport DHA poorly to the brain. High dose dietary DHA (fatty fish/supplements) is required to overcome this transport defect.

Heavy Metal Detox

ApoE4 is less efficient at clearing mercury/lead from the brain. Avoid high-mercury fish (swordfish/tuna) and support detox with cilantro/sweating.

Day 1 Brain Fuel
Breakfast
Coffee with MCT Oil
Ketones fuel the ApoE4 brain.
Lunch
Salmon Salad (SMASH)
Low mercury salmon.
Dinner
Kale & Beef Stir-Fry
Dark greens aid detox.
Day 2 Low Glycemic
Breakfast
3 Eggs & Avocado
Choline protects brain.
Lunch
Sardines in Olive Oil
High DHA, low mercury.
Dinner
Chicken & Broccoli
Simple, low inflammation.
Day 3 Detox Support
Breakfast
Cilantro Omelet
Cilantro binds heavy metals.
Lunch
Lentil Soup
Fiber binds toxins in gut.
Dinner
Cruciferous Vegetable Bake
Sulforaphane boosts glutathione.
Day 4 Ketone Boost
Breakfast
Coconut Yogurt
MCTs in coconut.
Lunch
Mackerel Salad
High fat brain food.
Dinner
Steak & Asparagus
Zero carb dinner.
Day 5 Fasting Window
Breakfast
Black Coffee/Tea
16 hour fast for autophagy.
Lunch
Cobb Salad
Break fast with nutrient density.
Dinner
Baked Cod & Greens
Lean protein.
Day 6 Gut Brain Axis
Breakfast
Kimchi & Eggs
Probiotics.
Lunch
Walnut & Berry Salad
Polyphenols for brain.
Dinner
Pork Chops & Sauerkraut
Fermented sides.
Day 7 Maintenance
Breakfast
Scrambled Eggs
Simple start.
Lunch
Mediterranean Plate
Olive oil focus.
Dinner
Roast Chicken
Whole food.

Get a plan for your exact biomarkers

Don't guess your nutrition. Our AI analyzes your lab results to find the perfect balance of 160+ nutrients for your unique biology.

Analyze My Results Now
Protocol Guidelines & Science
Saturated Fat?

The response to saturated fat in ApoE4 is controversial. Monitor LDL-C/ApoB. If they spike, replace butter/beef with olive oil/fish/poultry.

Sleep

The brain cleans itself (glymphatic system) during deep sleep. For ApoE carriers, 8 hours of sleep is a non-negotiable medical necessity.

Scientific References:
1. Bredesen, D. E. (2014). 'Reversal of cognitive decline: a novel therapeutic program.' Aging.
2. Yassine, H. N., et al. (2017). 'Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers.' JAMA Neurology.